2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel
  5. TRPM7 Isoform

TRPM7

TRPM7 is a TRP melastatin channel-kinase that conducts divalent and monovalent cations and combines channel and enzymatic activities[1]. Mechanistically, vascular TRPM7 supports Mg2+ homeostasis and regulates vascular smooth muscle cell growth, apoptosis, adhesion, contraction, cytoskeletal organization, and migration[2]. In inflammation, TRPM7 channel and kinase activity regulate neutrophil transmigration and reactive oxygen species production through Akt/mTOR signaling[3]. In intestinal disease models, TRPM7 knockdown reduces LPS-induced apoptosis and inflammatory cytokine expression by modulating TLR4/NF-κB and MEK/ERK pathways[4]. In kidney fibrosis models, TRPM7 expression increases after unilateral ureteral obstruction, while the inhibitor NS8593 reduces tubular and interstitial cell proliferation and TGF-β1/Smad signaling[5]. Compared with related TRPM6, which is found primarily in epithelial cells, TRPM7 is ubiquitously expressed, making it a broader experimental target for ion-homeostasis and disease-mechanism studies[2]. For pharmacological research, carvacrol inhibits TRPM7 current and reduces neonatal hypoxic-ischemic brain injury, whereas CBGA suppresses TRPM7 currents through a kinase-domain-dependent mechanism[6][7].

TRPM7 Related Products (1):

Cat. No. Product Name Effect Purity
  • HY-168608
    TRPM7-IN-1
    		Inhibitor 98.83%
    TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function.